Atheroma and the inflammasome

نویسندگان

چکیده

منابع مشابه

The nature of atheroma.

Atherosclerosis represents a heterogenous group of pathological phenomena involving degenerative, inflammatory and proliferative processes which produce lesions containing mainly cellular material, lipid, collagen and calcium. Despite the varying pathological forms, the clinical sequelae of atherosclerosis are well defined and affect coronary, cerebrovascular and peripheral arteries. The Office...

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The nature of atheroma

Atherosclerosis represents a heterogenous group of pathological phenomena involving degenerative, inflammatory and proliferative processes which produce lesions containing mainly cellular material, lipid, collagen and calcium. Despite the varying pathological forms, the clinical sequelae of atherosclerosis are well defined and affect coronary, cerebrovascular and peripheral arteries. The Office...

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Lipid keratopathy and atheroma.

THE purpose of the preselnt paper is to point out certain similarities in fatty plaques of the cornea aiid of blood vessels, both in manl anid ini hypercholesteremic rab)bits, and to suggest a commoim pathogenesis. The following resume is based onl a (clinieopathologic study of approximately a dozen cases of lipid plaques ill the humiiani cornea, approximately the sanme number ill the rabbit co...

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Insulin and atheroma.

Many clinical studies have shown an increased insulin response to oral glucose in patients with ischemia of the heart, lower limbs, or brain. Hyperinsulinemia also occurs in patients with angiographically proved atherosclerosis without ischemia and thus appears to be related to arterial disease and not to be a nonspecific response to tissue injury. Fasting insulin levels and insulin responses t...

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The inflammasome

What is it? The inflammasome is a multiprotein complex of more than 700 kDa that is responsible for the activation of caspases 1 and 5, leading to the processing and secretion of the pro-inflammatory cytokines IL-1β and IL-18. Two types of inflammasome have been identified to date — the NALP1 inflammasome, composed of NALP1, the adaptor protein ASC, caspase 1 and caspase 5, and the NALP2/3 infl...

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ژورنال

عنوان ژورنال: Journal of Nuclear Cardiology

سال: 2015

ISSN: 1071-3581,1532-6551

DOI: 10.1007/s12350-015-0086-7